![]() ![]() In total 549 men (53%) underwent 6 biopsies 460 (45%), 7 biopsies and 22 (2%), 8 biopsies. The study was approved by the local Medical Ethics Committee (MEC-2018-1614). For each patient, GS, grade group, total number of biopsies, number of prostate cancer–positive biopsies, and tumor volume were recorded. 12– 15 In case no slides were present for review or if metastasis was present at time of diagnosis, cases were excluded. Three investigators reviewed all prostate biopsies according to the WHO and International Society of Urological Pathology (ISUP) 2014 guidelines. Each individual biopsy core was embedded in a separate container to enable detailed pathologic evaluation. 10, 11 Participating men underwent sextant prostate biopsies according to the study protocol, with addition of a seventh or eighth biopsy in case of a hypoechoic lesion on transrectal ultrasonography. #Prostate volume calculator trial#Prostate biopsy cores were taken in the scope of the European Randomized Study of Screening for Prostate Cancer (ERSPC), initial screening round between November 1993 and March 2000, whose trial protocol has been published previously. The aim of this study was to compare different tumor volume parameters in relation to clinical outcome in a large prostate biopsy cohort. 8, 9 It is yet unknown to what extent tumor volume parameters are mutually related and whether they all have similar prognostic value. 4– 7 In addition, biopsy tumor involvement is a threshold for patient eligibility in some active surveillance protocols, underlining the need for objective and reliable tumor volume quantification. 2, 3 Biopsy tumor volume has been associated with outcome after radical prostatectomy (RP) and radiation therapy (RT) however, tumor volume representation varies amongst studies. ![]() 1 The College of American Pathologists and the World Health Organization (WHO) state that either linear cancer volume or proportion of prostate tissue involved by cancer should be reported as parameter for biopsy tumor volume. Apart from Gleason score (GS) and number of positive biopsies, an indication of tumor volume should be provided in pathology reports. Men suspected of having prostate cancer undergo biopsies to determine the presence and aggressiveness of a potential tumor. ![]()
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